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6-Thioguanine, Tocris Bioscience™

Catalog No. 406150
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50 mg
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Catalog No. Quantity
40-615-0 50 mg
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Catalog No. 40-615-0 Supplier R&D Systems Supplier No. 4061/50
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Description

Anticancer and immunosuppressive agent

Anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 5 μM for PLpro deubiquitination activity).

Chemical Identifiers

CAS 154-42-7
Molecular Formula C5H5N5S
Molecular Weight (g/mol) 167.19
MDL Number MFCD00233553
InChI Key WYWHKKSPHMUBEB-UHFFFAOYSA-N
Synonym 6-thioguanine, thioguanine, tioguanine, 2-amino-6-mercaptopurine, 6-mercaptoguanine, tioguanin, tabloid, lanvis, 2-amino-6-purinethiol, 2-aminopurine-6-thiol
PubChem CID 2723601
ChEBI CHEBI:9555
IUPAC Name 2-amino-6,7-dihydro-3H-purine-6-thione
SMILES NC1=NC(=S)C2=C(N1)N=CN2

Specifications

Quantity 50 mg
Formula Weight 167.19
Percent Purity >99%
Chemical Name or Material 6-Thioguanine

Safety and Handling

Recommended Storage Store at Room Temperature
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