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6-Thioguanine, Tocris Bioscience™

Catalog No. 406150
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Anticancer and immunosuppressive agent

Anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 5 μM for PLpro deubiquitination activity).

Chemical Identifiers

CAS 154-42-7
Molecular Formula C5H5N5S
Molecular Weight (g/mol) 167.19
MDL Number MFCD00233553
InChI Key WYWHKKSPHMUBEB-UHFFFAOYSA-N
Synonym 6-thioguanine, thioguanine, tioguanine, 2-amino-6-mercaptopurine, 6-mercaptoguanine, tioguanin, tabloid, lanvis, 2-amino-6-purinethiol, 2-aminopurine-6-thiol
PubChem CID 2723601
ChEBI CHEBI:9555
IUPAC Name 2-amino-6,7-dihydro-3H-purine-6-thione
SMILES NC1=NC(=S)C2=C(N1)N=CN2

Specifications

Quantity 50 mg
Formula Weight 167.19
Percent Purity >99%
Chemical Name or Material 6-Thioguanine

Safety and Handling

Recommended Storage Store at Room Temperature
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