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ABclonal Technology 647 Rabbit anti-Human CD204
Supplier: ABclonal Technology A25613200T
This gene encodes class A macrophage scavenger receptors which produce three isoforms (1 2 and 3) via alternative splicing These trimeric integral membrane glycoproteins are macrophage-specific and involved in various processes like atherosclerosis Alzheimer s disease and host defense Isoforms 1 and 2 mediate the endocytosis of modified low-density lipoproteins (LDLs) while isoform 3 despite having the necessary domain cannot internalize modified LDL due to altered intracellular processing and trapping within the endoplasmic reticulum Isoform 3 also inhibits the function of isoforms 1 and 2 when co-expressed suggesting a regulatory mechanism for scavenger receptor activity in macrophages
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