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ABclonal Technology 647 Rabbit anti-Human CD40
SDP

Supplier:  ABclonal Technology A21947500T

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This gene is part of the TNF-receptor superfamily and encodes a receptor on antigen-presenting cells that mediates immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation The transcription factor AKNA regulates the receptor and its ligand which is important for cell interactions TNFR2 interacts with this receptor mediating signal transduction The receptor-ligand interaction is critical for amyloid-beta-induced microglial activation an early event in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple alternatively spliced variants encoding different isoforms have been identified

Catalog No. 50-000-06549


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