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Medchemexpress LLC 6H-Purine-6-thione, 1,2,3,9-tetrahydro-, hydrate (1:1) | 6112-76-1 | 99.9% | 170.19 | 500 MG
Supplier: Medchemexpress LLC HY13677A500MG
6-Mercaptopurine hydrate is a purine analogue that acts as an antagonist of endogenous purines. It has been widely used as an antileukemic agent and immunosuppressive agent.
- Induces NR4A3 transcriptional activity.
- Increases NR4A3 protein levels.
- Increases cell surface GLUT4 in basal and insulin-stimulated cells.
- Increases phospho-AS160.
- Significantly inhibits EcSTH-induced phosphorylation of AMPK and ACC1.
- Promotes an increase in S phase cell population in fetal telencephalons.
- Promotes an increase in G2/M phase cell population in fetal telencephalons.
- Increases sub-G1 phase cell population (apoptotic cells).
- Inhibited expression of CAV1 protein in MM1S cells.
- Further promoted bortezomib-mediated survival of MM-bearing mice.
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