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Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG
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Supplier:  Medchemexpress LLC HY13095110MG

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Thalidomide-O-C6-COOH is a thalidomide-based cereblon (CRBN) E3 ligase ligand-linker conjugate terminating in a six-carbon carboxylic acid. It is used as a building block in PROTAC synthesis and chemical biology research, providing a convenient carboxylic acid handle for linker attachment and efficient recruitment of CRBN.

  • Used in PROTAC design to recruit cereblon (CRBN) E3 ligase.
  • Thalidomide-based ligand with a six-carbon carboxylic acid linker.
  • High purity, 99.3% (reported).
  • Soluble ≥100 mg/mL in DMSO.
  • Off-white to light yellow solid suitable for synthesis.
  • Molecular formula C20H22N2O7; molecular weight 402.40 g·mol⁻1.
  • Storage recommendations provided for powder and solutions to maintain stability.

Catalog No. 50-002-61970


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