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Medchemexpress LLC 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carb | 1231889-53-4 | MFCD30470964 | 99.1% | 502.56 g·mol⁻¹ | C31H26N4O3 | 25 MG
SDP

Catalog No. 5000246816
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BMS-935177 is a reversible, selective small-molecule inhibitor of Bruton's tyrosine kinase (BTK) for research use. It exhibits low-nanomolar biochemical potency and has been characterized for activity in cellular assays and oral efficacy in animal models relevant to B-cell signaling and immune modulation.

  • Low-nanomolar BTK inhibition (IC50 3 nM).
  • Cellular activity inhibiting calcium flux (IC50 27 nM) and CD69 expression.
  • Reduces TNFα production in PBMC assays (IC50 14 nM).
  • Demonstrated oral efficacy in rodent models with dose-dependent disease reduction.
  • Solid, light yellow to yellow; purity 99.11%.
  • Recommended storage: powder -20°C (long term); in solvent -80°C.

Catalog No. 50-002-46816 Supplier Medchemexpress LLC Supplier No. HY10179325MG
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BMS-935177 is a reversible, selective small-molecule inhibitor of Bruton's tyrosine kinase (BTK) for research use. It exhibits low-nanomolar biochemical potency and has been characterized for activity in cellular assays and oral efficacy in animal models relevant to B-cell signaling and immune modulation.

  • Low-nanomolar BTK inhibition (IC50 3 nM).
  • Cellular activity inhibiting calcium flux (IC50 27 nM) and CD69 expression.
  • Reduces TNFα production in PBMC assays (IC50 14 nM).
  • Demonstrated oral efficacy in rodent models with dose-dependent disease reduction.
  • Solid, light yellow to yellow; purity 99.11%.
  • Recommended storage: powder -20°C (long term); in solvent -80°C.

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