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Medchemexpress LLC 7,4'-Dihydroxyflavone | 2196-14-7 | 25 MG
Supplier: Medchemexpress LLC 25MGHYN2609
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis. It functions as an eotaxin/CCL11 inhibitor and a CBR1 inhibitor with an IC50 of 0.28 μM. This compound suppresses eotaxin production and prevents dexamethasone (Dex)-paradoxical adverse effects. Furthermore, 7,4'-DHF inhibits MUC5AC gene expression, mucus production, and secretion by regulating NF-κB, STAT6, and HDAC2, decreasing PMA-stimulated MUC5AC expression in NCI-H292 human airway epithelial cells with an IC50 of 1.4 μM.
- Purity: 99.64%
- Molecular weight: 254.24
- Formula: C15H10O4
- CAS number: 2196-14-7
- Appearance: Solid, light yellow to yellow
- Structure classification: Flavonoids, Flavones, Phenols, Polyphenols
- Acts as eotaxin/CCL11 and CBR1 inhibitor (IC50: 0.28 μM)
- Inhibits MUC5AC gene expression and mucus production
- IC50: 1.4 μM (NCI-H292 human airway epithelial cell)
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