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Cayman Chemical 7-Acetoxy-4-methylcoumarIn 1g
Supplier: Cayman Chemical 389091 G
An inhibitor of USP8 (IC50 280 nM) selective for USP8 over USP7 (IC50 100 UM) increases the level of PD-L1 in H460 cells at 2 UM and PC-9 cells at 2 and 4 UM decreases tumor weight tumor size and lung metastasis and increases CD8 T cell numbers within the primary tumor in a 4T1 murine mammary carcinoma model at 1 mg/kg every other day i.p. when combined with an anti-PD-L1 antibody and paclitaxel
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