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AdipoGen 7-Azido-4-methylcoumarin
Supplier: AdipoGen CDXA0069M001
Chemical. CAS 95633-27-5. Formula C10H7N3O2. MW 201.18. Synthetic 7-Azido-4-methylcoumarin is a highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin AMC with a concomitant increase in fluorescence with lambdaex = 365 nm and lambdaem = 450 nm. It is a photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 SULT1A1. 7-Azido-4-methylcoumarin is a tool for monitoring the activity of pyridoxal-5-phosphate PLP-dependent enzymes e.g. cystathionine beta-synthase CBS, cystathionine gamma-lyase CGL and tryptophan synthase TS and to identify novel cystathionine beta-synthase CBS inhibitors and activators.
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