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AdipoGen 7-Dehydrocholesterol
SDP

Supplier:  AdipoGen CDXD0331G010

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Chemical. CAS 434-16-2. Formula C27H44O. MW 384.64. Synthetic Precursor of cholesterol and vitamin D3. It is reduced to cholesterol by the enzyme 3beta-hydroxysterol-Delta7-reductase DHCR7 in the last step of cholesterol biosynthesis. Mutations in the gene encoding DHCR7 lead to increased levels of 7-DHC and the neurodevelopmental syndrome Smith-Lemli-Opitz syndrome SLOS. 7-DHC is used as a biomarker for SLOS screenings. Inhibits human fibroblast sphingomyelinase. Shown to have cytotoxic effects on melanoma cells. In skin, photolysis of 7-DHC by ultraviolet light produces vitamin D3. UV/Vis lambdamax 271, 282, 293nm.

Catalog No. 50-256-1115


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