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Cayman Chemical 7-MethoxycoumarIn 25g
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Supplier:  Cayman Chemical 3085725 G

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An allosteric antagonist of CXCR1 and CXCR2 (IC50s 43 and 0 97 nM respectively) inhibits CXCL8-induced chemotaxis of Ba/F3 cells expressing human recombinant CXCR2 and CXCL1-induced chemotaxis of isolated human PMNs at 3 nM inhibits LPS-induced neutrophil infiltration into the lung (ED50 1 8 mg/kg) and increases mucin levels in BALF in a rat model of airway inflammation inhibits proliferation of wild-type (IC50s 28 95 and 18 78 UM respectively) and IL-8 overexpressing HCT116 and Caco-2 cells (IC50s 39 45 and 25 45 UM respectively) reduces tumor growth in an HCT116 mouse xenograft model at 50 mg/kg per day

Catalog No. 50-298-9827


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