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Medchemexpress LLC 7-Methylguanine | 578-76-7 | 99.9% | 165.15 | 100 MG
SDP

Catalog No. 5000438552
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7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. As a metabolite of nucleic acids, it shows anticancer properties against uterine sarcoma and colon adenocarcinoma. It also acts as a valuable probe for investigating protein-DNA interactions and does not induce DNA damage in NKE-hTERT cells at tested concentrations.

  • Orally active and competitive PARP-1 inhibitor (Ki 61 μM)
  • Metabolite of nucleic acids
  • Anticancer activity against uterine sarcoma and colon adenocarcinoma
  • Probe for studying protein-DNA interactions
  • No DNA damage in NKE-hTERT cells at tested concentrations
  • Low in vivo toxicity at 50 mg/kg orally
  • Inhibits tumor growth in uterine sarcoma and colon adenocarcinoma models
  • Solid, white to light yellow form
  • Store at 4°C protected from light; in solvent, -80°C for 6 months or -20°C for 1 month

Catalog No. 50-004-38552 Supplier Medchemexpress LLC Supplier No. HY113352100MG
May include imposed supplier surcharges.
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7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. As a metabolite of nucleic acids, it shows anticancer properties against uterine sarcoma and colon adenocarcinoma. It also acts as a valuable probe for investigating protein-DNA interactions and does not induce DNA damage in NKE-hTERT cells at tested concentrations.

  • Orally active and competitive PARP-1 inhibitor (Ki 61 μM)
  • Metabolite of nucleic acids
  • Anticancer activity against uterine sarcoma and colon adenocarcinoma
  • Probe for studying protein-DNA interactions
  • No DNA damage in NKE-hTERT cells at tested concentrations
  • Low in vivo toxicity at 50 mg/kg orally
  • Inhibits tumor growth in uterine sarcoma and colon adenocarcinoma models
  • Solid, white to light yellow form
  • Store at 4°C protected from light; in solvent, -80°C for 6 months or -20°C for 1 month

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