Medchemexpress LLC 7-Methylguanine | 578-76-7 | 99.9% | 165.15 | 100 MG

Supplier:  Medchemexpress LLC HY113352100MG

7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. As a metabolite of nucleic acids, it shows anticancer properties against uterine sarcoma and colon adenocarcinoma. It also acts as a valuable probe for investigating protein-DNA interactions and does not induce DNA damage in NKE-hTERT cells at tested concentrations.

• Orally active and competitive PARP-1 inhibitor (Ki 61 μM)
• Metabolite of nucleic acids
• Anticancer activity against uterine sarcoma and colon adenocarcinoma
• Probe for studying protein-DNA interactions
• No DNA damage in NKE-hTERT cells at tested concentrations
• Low in vivo toxicity at 50 mg/kg orally
• Inhibits tumor growth in uterine sarcoma and colon adenocarcinoma models
• Solid, white to light yellow form
• Store at 4°C protected from light; in solvent, -80°C for 6 months or -20°C for 1 month

Catalog No. 50-004-38552