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Cayman Chemical 7AADCFSE CelMedIATd Cyto 1ea
Supplier: Cayman Chemical 6001201 EA
A dual peptide agonist of GLP-1R and GCGR increases cAMP accumulation in CHO-K1 cells expressing GLP-1R or GCGR in reporter assays (EC50s 0.33 and 0.52 nM respectively) potentiates glucose-induced insulin secretion in isolated mouse rat and perifused human pancreatic islets reduces body weight and food intake in diet-induced obese mice at 3 and 30 nmol/kg per day reduces the levels of hepatic triglycerides and cholesterol as well as plasma levels of glucagon cholesterol triglycerides ALT AST insulin and leptin in diet-induced obese mice increases energy expenditure in diet-induced obese mice at 10 nmol/kg per day
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