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Medchemexpress LLC 8-chloro-2-((2,4-dichlorophenyl)amino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one | 1361227-90-8 | 99.9% | 468.72 | C20H16Cl3N3O4 | 25MG
SDP

Catalog No. 5000239229
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JH-RE-06 is a small-molecule inhibitor that disrupts the REV1-REV7 interface, preventing recruitment of mutagenic POLζ and enhancing tumor cell sensitivity to DNA-damaging agents. It is provided for research use with reported activity data and analytical documentation available.

  • Targets the REV1-REV7 interface to disrupt mutagenic translesion synthesis.
  • Reported IC50 0.78 μM and Kd 0.42 μM for activity characterization.
  • Chemical formula C20H16Cl3N3O4 and molecular weight 468.72 g·mol⁻¹.
  • High purity: 99.87% (reported).
  • Available in multiple solid sizes including 25 mg and as 10 mM solution in DMSO.
  • Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
  • Analytical documentation includes datasheet, COA, SDS, and LCMS.

Catalog No. 50-002-39229 Supplier Medchemexpress LLC Supplier No. HY12621425MG
May include imposed supplier surcharges.
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JH-RE-06 is a small-molecule inhibitor that disrupts the REV1-REV7 interface, preventing recruitment of mutagenic POLζ and enhancing tumor cell sensitivity to DNA-damaging agents. It is provided for research use with reported activity data and analytical documentation available.

  • Targets the REV1-REV7 interface to disrupt mutagenic translesion synthesis.
  • Reported IC50 0.78 μM and Kd 0.42 μM for activity characterization.
  • Chemical formula C20H16Cl3N3O4 and molecular weight 468.72 g·mol⁻¹.
  • High purity: 99.87% (reported).
  • Available in multiple solid sizes including 25 mg and as 10 mM solution in DMSO.
  • Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
  • Analytical documentation includes datasheet, COA, SDS, and LCMS.

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