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Enzo Life Sciences 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3,5-cyclic Monophosphate . sodium salt (5mg). CAS: 510774-50-2
Supplier: Enzo Life Sciences ALX480093M005
Specific, potent and membrane permeant activator of the Epac cAMP receptor. Activates Epac1 and Epac2, the guanine nucleotide-exchange factors (GEFs) for the small GTPases Rap1 and Rap2. Does not activate protein kinase A (PKA), neither in vitro nor in vivo and is therefore a valuable tool to specifically discriminate between PKA- and Epac-mediated effects. Since a free 2'-ribose hydroxyl group in cyclic AMP is essential for stimulation of PKA, the methylated structure of 8-CPT-2'-O-Me-cAMP is an extremely poor PKA activator. Its high lipophilicity allows for good membrane permeability in most biosystems and its increased resistance towards phosphodiesterases prevents rapid hydrolysis. Alternative name: 8-CPT-2'-O-Me-cAMP . Na. Purity: ≥98% (HPLC). Solubility: Soluble in water, aqueous buffers, DMSO, dimethyl formamide or methanol. Long Term Storage: -20°C.
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