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AdipoGen 8-Prenylnaringenin (1 mg)
SDP

Supplier:  AdipoGen AGCN20525M001

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Chemical. CAS: 53846-50-7. Formula: C20H20O5. MW: 340.4. Prenylflavonoid non-steroidal phytoestrogen that mimicks and/or modulates endogenous estrogens via estrogen receptor binding. Inhibits both isoforms of the human estrogen receptor (ER; IC50s = 57nM and 68nM for ERalpha and ERbeta, respectively). Acts as a full agonist of ERalpha. Cancer chemopreventive agent. Shown to decrease ROS and increase the oxidative phosphorylation system (OXPHOS). Anticancer agent with antiangiogenic and antiproliferative properties. Shown to inhibit cell cycle progression, induce apoptosis in MCF-7 cells and induce autophagy in prostate cancer cell lines. Potent aromatase inhibitor (IC50=65nM) and cellular histone deacetylases (HDACs) inhibitor. Anti-diabetic agent. Anti-osteoporetic agent. Anti-inflammatory and vascularprotective compound. Potential lead structure for potential new therapeutic agents.

Catalog No. 50-205-3697


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