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Cayman Chemical 8Methoxymethyl3Isobutyl1 10mg
Supplier: Cayman Chemical 3915110 MG
A PDE1 inhibitor (IC50 = 5 µM); selective for PDE1 over PDE2, PDE3, and PDE4 but also inhibits PDE5 (IC50s = 37, >400, >400, and 2 µM, respectively); enhances forskolin-induced increases in intracellular calcium levels in isolated rat olfactory receptor neurons at 30 µM; induces relaxation of isolated human saphenous vein segments in the absence of endothelium (EC50 = 31 µM); enhances iloprost-induced decreases in pulmonary artery pressure and vascular resistance in a rabbit model of U-46619-induced pulmonary hypertension at 200 UG/kg
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