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Medchemexpress LLC 9-Decyn-1-ol | 17643-36-6 | 25 G
Supplier: Medchemexpress LLC 25GHY130985
9-Decyn-1-ol is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. It can be employed to conjugate GDC-0068 with Lenalidomide to generate INY-03-041, which is described as a potent, highly selective, and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2, and Akt3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. Additionally, 9-Decyn-1-ol functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- Utilized in the synthesis of PROTACs.
- Functions as a click chemistry reagent.
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition.
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