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Medchemexpress LLC 9-Decyn-1-ol | 17643-36-6 | 50 G
Supplier: Medchemexpress LLC HY13098550G
9-Decyn-1-ol is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. It can conjugate GDC-0068 with Lenalidomide to create INY-03-041, a potent, highly selective, and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2, and Akt3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Generates a potent, highly selective, PROTAC-based pan-Akt degrader
- Click chemistry reagent with an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
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