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Cayman Chemical 9-Phenthrol 50mg
Supplier: Cayman Chemical 1524850 MG
A TRPM4 inhibitor (IC50s = 19.1, 17.1, and 22.8 µM at +40, -40, and -80 mV, respectively, in HEK293 cells expressing the human receptor); selective for TRPM4 over TRPM5 at 100 µM; reduces heart rate in spontaneously beating isolated mouse right atria at 100 µM; reduces infarct size and apoptosis in isolated rat hearts in an ex vivo model of ischemia-reperfusion injury; reduces myogenic tone in rat cerebral arteries in vivo
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