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Medchemexpress LLC 9H-Purin-6-amine, 9-(1-methylethyl)-N-[[3-(trifluoromethyl)phenyl]methyl]- | 1353867-91-0 | 99.8% | 335.33 | 200 MG
SDP

Supplier:  Medchemexpress LLC HY18285200MG

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Longdaysin is an inhibitor of the Wnt/β-catenin signaling pathway, exerting antitumor effects by blocking CK1δ/ε-dependent Wnt signaling. It inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of 5.6 μM, 8.8 μM, 29 μM, and 52 μM, respectively.

  • Inhibitor of the Wnt/β-catenin signaling pathway.
  • Exerts antitumor effects by blocking CK1δ/ε-dependent Wnt signaling.
  • Inhibits CK1α, CK1δ, CDK7, and ERK2.
  • Lengthens circadian period in adult tail fibroblasts, lung explants, and SCN explants.
  • Inhibits colony formation, migration, invasion, and sphere formation of breast cancer cells.
  • Increases circadian period in zebrafish.
  • Inhibits tumor growth in xenograft mice.

Catalog No. 50-003-87553


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