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Apexbio Technology LLC A-1155463 1235034-55-5 5mg
Supplier: Apexbio Technology LLC B61635
A-1155463 (CAS 1235034-55-5) is a potent and selective small-molecule inhibitor of the anti-apoptotic protein BCL-XL exhibiting a Ki of 19 nM Developed through NMR fragment screening and structure-guided optimization A-1155463 demonstrates higher efficacy against BCL-XL-dependent cell lines compared to earlier inhibitors such as WEHI-539 In murine models administration of A-1155463 induces transient thrombocytopenia and inhibits the growth of BCL-XL-dependent H146 xenograft tumors supporting its utility for mechanistic studies on BCL-XL in tumor cell survival and therapeutic resistance The compound remains in preclinical research stages
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