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Apexbio Technology LLC A-317491(Synonyms: A317491, A-317491 sodium salt hydrate, P2X3 receptor antagonist A-317491, A 317491), 5mg, CAS: 475205-49-3.
Supplier: Apexbio Technology LLC A31345
A-317491 (CAS 475205-49-3) is a selective high-affinity antagonist targeting the P2X3 and heteromeric P2X2/3 receptors ligand-gated ion channels responsive to ATP primarily located on sensory neurons involved in pain signaling It demonstrates potent inhibition with reported Ki values of 9 nM (P2X2/3) and 22 nM (P2X3) In rat dorsal root ganglion neurons A-317491 suppresses receptor-mediated currents (IC50 15 nM) in a dose-dependent manner In animal models intrathecal or peripheral administration attenuates hyperalgesia associated with inflammation and neuropathic pain underscoring its utility in pain research
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