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Medchemexpress LLC A-395 hydrochloride | 2089148-72-9 | MFCD31563589 | >98.0% | 486.65 g/mol | C26H35FN4O2S · xHCl | 25 MG
SDP

Catalog No. 5000246606
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A-395 hydrochloride is a small-molecule chemical probe that antagonizes polycomb repressive complex 2 (PRC2) protein-protein interactions by binding the EED subunit and inhibiting the trimeric PRC2 complex. It is used in biochemical and cellular studies to probe epigenetic regulation of H3K27 methylation.

  • Potent PRC2 inhibition with reported IC50 in the low nanomolar range.
  • Selective EED binding reduces H3K27me3 levels in cellular assays.
  • Suitable for in vitro biochemical assays and cellular studies.
  • Available as the hydrochloride salt to improve handling and solubility.
  • Typical supplier purity ≥98.0% by HPLC.
  • Molecular weight ~486.65 g/mol (free base) for dosing calculations.

Catalog No. 50-002-46606 Supplier Medchemexpress LLC Supplier No. HY10151225MG
May include imposed supplier surcharges.
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A-395 hydrochloride is a small-molecule chemical probe that antagonizes polycomb repressive complex 2 (PRC2) protein-protein interactions by binding the EED subunit and inhibiting the trimeric PRC2 complex. It is used in biochemical and cellular studies to probe epigenetic regulation of H3K27 methylation.

  • Potent PRC2 inhibition with reported IC50 in the low nanomolar range.
  • Selective EED binding reduces H3K27me3 levels in cellular assays.
  • Suitable for in vitro biochemical assays and cellular studies.
  • Available as the hydrochloride salt to improve handling and solubility.
  • Typical supplier purity ≥98.0% by HPLC.
  • Molecular weight ~486.65 g/mol (free base) for dosing calculations.

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