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Medchemexpress LLC A 438079 hydrochloride | 899431-18-6 | C13H10Cl3N5 | 1 ML
Supplier: Medchemexpress LLC HY15488A10MM/1ML
A 438079 hydrochloride is a potent and selective P2X7 receptor antagonist with a pIC50 of 6.9, suitable for research applications. It blocks BzATP-evoked changes in intracellular calcium concentrations with an IC50 of 321 nM in rat P2X7 receptor-expressing cells, showing selectivity up to 100 μM. It has demonstrated efficacy in reducing pain and seizure severity in various in vivo models.
- Potent and selective P2X7 receptor antagonist
- Blocks BzATP-evoked intracellular calcium changes
- Selective for P2X7 receptor
- Reduces noxious and innocuous evoked activity in neuropathic rats
- Raises withdrawal thresholds in SNL and CCI models
- Reduces seizure severity and neuronal death
- Prevents 6-OHDA-induced depletion of striatal dopamine stores
- Reduces nociceptive behavior
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