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Medchemexpress LLC A 438079 hydrochloride | 899431-18-6 | C13H10Cl3N5 | 100 MG
Supplier: Medchemexpress LLC HY15488A100MG
A 438079 hydrochloride is a potent and selective antagonist of the P2X7 receptor, with a pIC50 of 6.9. It blocks BzATP-evoked changes in intracellular calcium concentrations with an IC50 of 321 nM in 1321N1 cells expressing rat P2X7 receptors. This compound shows selectivity for the P2X7 receptor at concentrations up to 100 μM and has demonstrated neuroprotective effects in vivo.
- P2X7 receptor antagonist
- Reduces noxious and innocuous evoked activity of spinal neurons
- Raises withdrawal thresholds in neuropathic models
- Reduces seizure severity and neuronal death
- White to off-white solid appearance
- High purity of 99.99%
- Soluble in DMSO and H2O
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