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Apexbio Technology LLC A-674563 552325-73-2 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A86165.1

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A-674563 (CAS 552325-73-2) is a potent inhibitor of the serine/threonine kinase Akt1 (protein kinase B) with an IC50 of 14 nM It also demonstrates inhibitory activity against PKA and CDK2 with IC50 values of 16 nM and 46 nM respectively Akt regulates diverse cellular processes including proliferation apoptosis metabolism transcription and migration In cellular assays A-674563 suppresses proliferation in MiaPaCa-2 cells (EC50 0 4 M) reduces phosphorylation of GSK3 and MDM2 and induces G2-phase cell-cycle arrest and apoptosis in STS cells In mouse xenograft studies this inhibitor delays tumor growth and enhances paclitaxel efficacy illustrating its utility in oncology research

Catalog No. 50-000-62408


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