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Apexbio Technology LLC A-740003(Synonyms: A740003, A 740003, P2X7 Receptor Antagonist A-740003, A-740003 P2X7 Antagonist, 861393-28-4), 10mM (in 1mL DMSO), CAS: 861393-28-4.
Supplier: Apexbio Technology LLC A31365.1
A-740003 (CAS 861393-28-4) is a selective and competitive antagonist targeting the P2X7 receptor a member of the ATP-gated ionotropic P2X receptor family involved in immune cell signaling cytokine secretion apoptosis and cellular proliferation The antagonist displays IC50 values of 18 nM and 40 nM against mouse and human P2X7 receptors respectively In human THP-1 macrophage-like cells A-740003 inhibits pore formation assessed by Yo-Pro uptake assay (IC50 92 nM) and reduces interleukin-1 secretion (IC50 156 nM) This compound is employed in research investigating P2X7-mediated inflammatory pathways and neuropathic pain mechanisms
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