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Medchemexpress LLC A 779 | 159432-28-7 | 99.3% | 872.97 | 100 MG
Supplier: Medchemexpress LLC HYP0216100MG
A 779 is a specific antagonist of the G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor distinct from the classical AngII. It is for research use only.
- Inhibits the effect of Ang-(1-7)
- Suppresses PCNA protein expression up-regulated by Ang II
- Blocks Ang II-induced inflammatory responses of VSMCs
- Blocks Ang II-induced Akt and ERK1/2 phosphorylation
- Elevates serum BALP, CTX, TRAcP 5b, OC, and urinary DPD
- Abolishes Ang-(1-7)'s favorable effects on bone health by blocking the Mas receptor
- Erradicates captopril protective effects on bone metabolism, mineralization, and micro-structure
- Restores OVX effects on RANKL expression and ACE-1/AngII/AT1R cascade
- Down-regulates OPG expression and ACE-2/Ang1-7/Mas pathway
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