Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC A 83-01 909910-43-6 50mg
Supplier: Apexbio Technology LLC A313350
A 83-01 (CAS 909910-43-6) is a selective small-molecule inhibitor targeting activin receptor-like kinase 5 (ALK-5) with additional inhibitory effects on ALK-4 and ALK-7 It specifically blocks ALK-5-mediated signalling induced by TGF- suppressing downstream Smad-dependent transcription with an IC50 of approximately 12 nM Assays in Mv1LuR4-2 cells showed that at 1 M A 83-01 reduced ALK-5-induced luciferase reporter activity by 68% By targeting these ALK receptors A 83-01 is frequently utilized to investigate TGF- signaling pathways epithelial-mesenchymal transition and cellular growth inhibition in biological research
This item is not returnable.
View return policy
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?