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STEMCELL Technologies A 83-01, Size: 5 mg
Supplier: STEMCELL Technologies 72022
Inhibit activin receptor-like kinase (ALK), including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with A 83-01 (Tojo et al. Cancer Sci, 2005). A 83-01 inhibits mesoderm and endoderm specification (Zhang et al. Cell Stem Cell, 2016), facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al. J Biol Chem, 2010; Li et al. Cell Stem Cell, 2009), and disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al. Cancer Sci, 2005). In combination with PD0325901, A 83-01 also enables OCT4-mediated reprogramming (Zhu et al. Cell Stem Cell, 2010). A 83-01 is supplied as a crystalline solid with ≥ 95% purity; Molecular weight 421.5 g/mol; CAS number 909910-43-6. Visit STEMCELL.com for more information and related products.
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