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Medchemexpress LLC A-935142 | 1031335-85-9 | 98.8% | 352.35 | 1 MG
SDP

Catalog No. 5000436525
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A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. It enhances hERG current by facilitating activation, reducing inactivation, and slowing deactivation, which abbreviates atrial and ventricular repolarization.

  • For research use only.
  • Shortens the action potential duration (APD90) in guinea pig atrial tissue and canine cardiac Purkinje fibers.
  • Shortens cardiac action potentials and enhances the amplitude of the hERG current in a concentration- and voltage-dependent manner.
  • Increases both outward and inward K(+) current as well as the slope conductance of the linear portion of the fully activated I-V relation (60μM).
  • Significantly reduces the time constants τ of hERG channel activation and shifts the voltage-dependence for hERG activation in the hyperpolarizing direction by 9 mV.

Catalog No. 50-004-36525 Supplier Medchemexpress LLC Supplier No. HY1136731MG
May include imposed supplier surcharges.
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A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. It enhances hERG current by facilitating activation, reducing inactivation, and slowing deactivation, which abbreviates atrial and ventricular repolarization.

  • For research use only.
  • Shortens the action potential duration (APD90) in guinea pig atrial tissue and canine cardiac Purkinje fibers.
  • Shortens cardiac action potentials and enhances the amplitude of the hERG current in a concentration- and voltage-dependent manner.
  • Increases both outward and inward K(+) current as well as the slope conductance of the linear portion of the fully activated I-V relation (60μM).
  • Significantly reduces the time constants τ of hERG channel activation and shifts the voltage-dependence for hERG activation in the hyperpolarizing direction by 9 mV.

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