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Cayman Chemical a-KetoglutarIc AcIdodIum s 1g
Supplier: Cayman Chemical 90018281 G
An ACAT-1 inhibitor (IC50 0.45 UM) selective for ACAT-1 over ACAT-2 (IC50 102.85 UM) reduces cholesterol esterification in monocyte-derived macrophages (IC50 0.068 UM) decreases lipid-accumulation areas in the aortic arch in atherosclerosis-susceptible Bio F1B hamsters fed a high-fat and high-cholesterol diet at 10 mg/kg and reduces plasma total cholesterol levels in the same model at 10 and 30 mg/kg increases autophagosome formation in N2a cells at 0.1 and 1 UM decreases wild-type and mutant P301L-tau levels in N2a cells overexpressing these proteins but does not affect endogenous tau levels intranasal administration reduces the level of brain cholesteryl esters in mice at 105 UG/animal
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