Medchemexpress LLC Aβ/tau aggregation-IN-1 | 2252162-81-3 | 98.1% | C25H21IN2O | 50 MG

Supplier:  Medchemexpress LLC HY14166150MG

Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ1-42 β-sheets formation and tau aggregation, with KD values of 160 μM for Aβ1-42 and 337 μM for tau. This compound can permeate the blood-brain barrier. In vitro studies show it significantly reduces tau aggregation foci and inhibits Aβ1-42 aggregation by 84.7%-99.5%, and tau aggregation by 71.2%-101.8%.

• Potent inhibitor of Aβ1-42 β-sheets formation and tau aggregation
• Permeates the blood-brain barrier
• Significantly reduces tau aggregation foci in HEK-293 T cells
• Inhibits Aβ1-42 aggregation by 84.7%-99.5%
• Inhibits tau aggregation by 71.2%-101.8% through N-methylation of the quinolone ring
• Interacts with Aβ1-42 and tau via noncovalent interactions

Catalog No. 50-003-55396