ABclonal Technology SHIP1 Rabbit pAb

Supplier:  ABclonal Technology A01221000UL

This gene encodes a protein from the inositol polyphosphate-5-phosphatase (INPP5) family, containing an SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. It is expressed mainly in hematopoietic cells, where its translocation from the cytosol to the plasma membrane is regulated by tyrosine phosphorylation. At the plasma membrane, it hydrolyzes the 5 phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, influencing multiple signaling pathways. It also localizes to the nucleus, possibly participating in nuclear inositol phosphate signaling. The protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations are linked to immune system defects, cancers, and Inflammatory Bowel Diseases like Crohns and Ulcerative Colitis. Alternative splicing generates multiple transcript variants.

Catalog No. 50-001-38808