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ABclonal Technology A0166-1000ul VASP
Supplier: ABclonal Technology A01661000UL
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions In the mid-region of the protein family members have a proline-rich domain that binds SH3 and WW domain-containing proteins Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG
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