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ABclonal Technology Caspase-8 Rabbit pAb
SDP

Supplier:  ABclonal Technology A02151000UL

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This gene encodes a member of the caspase family, crucial for the execution phase of apoptosis. Caspases are synthesized as inactive proenzymes composed of a prodomain, and large and small subunits. Activation requires cleavage at conserved aspartic sites, forming a heterodimeric enzyme. This caspase is activated by Fas and other apoptotic signals and contains a FADD-like death effector domain, suggesting interaction with FADD. It has been detected in insoluble brain fractions of Huntingtons disease patients, indicating a possible role in neurodegeneration. Multiple alternatively spliced transcript variants exist, though not all full-length sequences are known.

Catalog No. 50-001-37327


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