ABclonal Technology A0296-1000ul ESR

Supplier:  ABclonal Technology A02961000UL

This gene encodes an estrogen receptor and ligand-activated transcription factor The canonical protein contains an N-terminal ligand-independent transactivation domain a central DNA binding domain a hinge domain and a C-terminal ligand-dependent transactivation domain The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2 The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth metabolism sexual development gestation and other reproductive functions and is expressed in many non-reproductive tissues The receptor encoded by this gene plays a key role in breast cancer endometrial cancer and osteoporosis This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing however the full-length nature of many of these variants remain uncertain

Catalog No. 50-001-38783