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ABclonal Technology Chk2 Rabbit pAb
SDP

Catalog No. 5000137413
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This gene encodes a cell cycle checkpoint regulator and putative tumor suppressor. The protein contains a forkhead-associated domain crucial for activation in response to DNA damage and replication blocks. Upon activation, it inhibits CDC25C phosphatase, preventing mitosis entry, and stabilizes the tumor suppressor p53, leading to G1 cell cycle arrest. It also interacts with and phosphorylates BRCA1, enabling DNA damage survival. Mutations in this gene are associated with Li-Fraumeni syndrome, linked to TP53 mutations, and increase the risk of sarcomas, breast cancer, and brain tumors. This nuclear protein belongs to the CDS1 subfamily of serine/threonine kinases, and several isoforms are produced through alternative splicing.

Catalog No. 50-001-37413 Supplier ABclonal Technology Supplier No. A0466500UL
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This gene encodes a cell cycle checkpoint regulator and putative tumor suppressor. The protein contains a forkhead-associated domain crucial for activation in response to DNA damage and replication blocks. Upon activation, it inhibits CDC25C phosphatase, preventing mitosis entry, and stabilizes the tumor suppressor p53, leading to G1 cell cycle arrest. It also interacts with and phosphorylates BRCA1, enabling DNA damage survival. Mutations in this gene are associated with Li-Fraumeni syndrome, linked to TP53 mutations, and increase the risk of sarcomas, breast cancer, and brain tumors. This nuclear protein belongs to the CDS1 subfamily of serine/threonine kinases, and several isoforms are produced through alternative splicing.

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