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ABclonal Technology NUP98 Rabbit pAb
Supplier: ABclonal Technology A0530500UL
This gene belongs to the nucleoporin family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to produce 98 kDa and 96 kDa nucleoporins. The 98 kDa nucleoporin, containing a Gly-Leu-Phe-Gly (GLGF) repeat, is involved in nuclear import, export, mitotic progression, and gene expression regulation. The 96 kDa nucleoporin is a scaffold component of the nuclear pore complex (NPC). Proteolytic cleavage is essential for targeting these proteins to the NPC. Translocations of this gene with other genes have been observed in leukemias, resulting in chimeras with the GLGF domain fused to the partner genes C-terminus. Alternative splicing generates multiple transcript variants, including those lacking the 96 kDa nucleoporin region and those processed proteolytically.
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