ABclonal Technology [KO Validated] ErbB3/HER3 Rabbit pAb

Supplier:  ABclonal Technology A0950500UL

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The protein has a neuregulin-binding domain but lacks an active kinase domain, so it can bind the ligand but cannot transmit the signal. However, it forms heterodimers with other EGFR family members with kinase activity, activating pathways that lead to cell proliferation or differentiation. Gene amplification or overexpression of this protein has been observed in cancers like prostate, bladder, and breast tumors. Alternate splice variants have been characterized, including one isoform that lacks the intermembrane region and is secreted outside the cell, where it modulates the activity of the membrane-bound form. Other splice variants have been reported but are not fully characterized.

Catalog No. 50-001-35007