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ABclonal Technology PATZ1 Rabbit pAb

Supplier: ABclonal Technology A10053500UL
This gene encodes a protein with an A-T hook DNA-binding motif, a POZ domain for protein interactions and transcriptional repression, and zinc fingers for DNA binding, suggesting a role as a transcriptional repressor. In small round cell sarcoma, a chromosome 22 inversion fuses this gene with EWS, forming a t(1;22)(p36.1;q12) translocation. This rearrangement joins the EWS transactivation domain with this protein’s zinc finger domain, creating a chimeric transcription factor. This fusion is an example of intra-chromosomal rearrangement. Four alternatively spliced transcript variants have been identified.
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