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ABclonal Technology A1098-1000ul HP1 alpha/CBX5
Supplier: ABclonal Technology A10981000UL
This gene encodes a highly conserved nonhistone protein which is a member of the heterochromatin protein family The protein is enriched in the heterochromatin and associated with centromeres The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins The gene has a pseudogene located on chromosome 3 Multiple alternatively spliced variants encoding the same protein have been identified
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