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ABclonal Technology β-TrCP/BTRC Rabbit pAb
Supplier: ABclonal Technology A1656500UL
This gene encodes an F-box protein, part of the F-box protein family, characterized by a 40 amino acid F-box motif. F-box proteins are subunits of the SCF (SKP1-cullin-F-box) complex, involved in phosphorylation-dependent ubiquitination. The F-box proteins are classified into three classes: Fbws, Fbls, and Fbxs. The protein encoded by this gene belongs to the Fbws class, containing both an F-box and multiple WD-40 repeats. It mediates CD4 degradation through interaction with HIV-1 Vpu and ubiquitinates phosphorylated NFKBIA, targeting it for degradation and activating nuclear factor kappa-B. Alternative splicing results in multiple transcript variants, and a related pseudogene exists on chromosome 6.
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