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Sigma Aldrich A1V1Pf2-Oet

Catalog No. 917710100MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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91-771-0100MG 5 mg
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Catalog No. 91-771-0100MG Supplier Sigma Aldrich Supplier No. 917710100MG
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

A1V1PF2-OEt is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. An N-terminal variant of A1V1PF2-OEt is also available as BocA1V1PF2 (917478). A1V1PF2-OEt conjugates are also available for degrader synthesis. Browse our full synthesis offering here: Browse our full synthesis offering here for streamlining SNIPER and PROTAC™ degrader libraries: Degrader Building Blocks 917427 A1V1PF2-OEt-C6-NH2 hydrochloride 917672 A1V1PF2-OEt-C10-NH2 hydrochloride 917923 A1V1PF2-OEt-PEG1-NH2 hydrochloride 916676 A1V1PF2-OEt-PEG3-NH2 hydrochlorideTechnology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived LigandsIn Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)SNIPERs-Hijacking IAP activity to induce protein degradationE3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New OnesPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

CAS 8019-8-7-3
Molecular Formula C50H63ClF3N5O12
Quantity 5 mg
Synonym (R)-1-(3-(1-(3-(2-Chloroacetamido)-5-(trifluoromethyl)phenyl)-1,5-dioxo-9,12-dioxa-2,6-diazapentadecan-15-amido)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate; Electrophilic PROTAC(R); Heterobifunctional conjugate for E3 ubiquitin ligase discovery
Molecular Weight (g/mol) 1018.51 g/mol
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