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Sigma Aldrich A1V2Pf1-Nhet

Catalog No. 917222100MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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Catalog No. 91-722-2100MG Supplier Sigma Aldrich Supplier No. 917222100MG
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

A1V2PF1-NHEt is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. An N-terminal variant of A1V2PF1-NHEt is also available as BocA1V2PF1 (916978).A1V2PF1-NHEt conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC™ degrader libraries: Degrader Building Blocks916943A1V2PF1-NHEt-C6-NH2917206A1V2PF1-NHEt-C10-NH2917451A1V2PF1-NHEt-PEG1-NH2917702 A1V2PF1-NHEt-PEG3-NH2Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived LigandsIn Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)SNIPERs-Hijacking IAP activity to induce protein degradationE3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New OnesPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

Molecular Formula C33H54N6O4
Linear Formula C33H54N6O4
Quantity 1 g
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