ABclonal Technology A8624-1000ul ITCH

Supplier:  ABclonal Technology A86241000UL

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates thus targeting specific proteins for lysosomal degradation The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses Mutations in this gene are a cause of syndromic multisystem autoimmune disease Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene

Catalog No. 50-001-34858