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Medchemexpress LLC Aaa-10 | 2758171-70-7 | 98.0% | C25H41FO5S | 10MG
SDP

Catalog No. 5000260249
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AAA-10 is an orally active inhibitor of gut bacterial bile salt hydrolases (BSH). It selectively inhibits bacterial BSH enzymes, showing IC50s of 10 nM against B. theta rBSH and 80 nM against B. longum rBSH, and has demonstrated inhibition of bile acid deconjugation in vitro and reduced levels of secondary bile acids (DCA, LCA) in mouse models after oral dosing.

  • Orally active BSH inhibitor for gut microbiome studies.
  • Low nanomolar potency against bacterial BSH enzymes.
  • Demonstrated activity in in vitro bile acid deconjugation assays.
  • Reduces secondary bile acid levels in vivo after oral dosing.
  • Available as a solid, white to off-white powder for storage and formulation.
  • Long-term powder stability at -20°C and short-term stability in solution at -80°C.

Catalog No. 50-002-60249 Supplier Medchemexpress LLC Supplier No. HY14514710MG
May include imposed supplier surcharges.
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AAA-10 is an orally active inhibitor of gut bacterial bile salt hydrolases (BSH). It selectively inhibits bacterial BSH enzymes, showing IC50s of 10 nM against B. theta rBSH and 80 nM against B. longum rBSH, and has demonstrated inhibition of bile acid deconjugation in vitro and reduced levels of secondary bile acids (DCA, LCA) in mouse models after oral dosing.

  • Orally active BSH inhibitor for gut microbiome studies.
  • Low nanomolar potency against bacterial BSH enzymes.
  • Demonstrated activity in in vitro bile acid deconjugation assays.
  • Reduces secondary bile acid levels in vivo after oral dosing.
  • Available as a solid, white to off-white powder for storage and formulation.
  • Long-term powder stability at -20°C and short-term stability in solution at -80°C.

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