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Medchemexpress LLC AAA-10 | 2758171-70-7 | 98.0% | C25H41FO5S | 50 MG
SDP

Supplier:  Medchemexpress LLC HY14514750MG

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AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM against B. theta rBSH and 80 nM against B. longum rBSH.

  • Inhibits BSH activity in bacterial cultures.
  • Significantly inhibits deconjugation of glycochenodeoxycholic acid-d4 or taurocholic acid-d4 substrates.
  • Decreases the abundances of deoxycholic acid (DCA) and lithocholic acid (LCA) in mice feces.
  • Displays high colonic exposure and low gut permeability.

Catalog No. 50-003-53363


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