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Medchemexpress LLC Abemaciclib metabolite M18 | 2704316-81-2 | 98.01% | 10 MG
Supplier: Medchemexpress LLC HY126534A10MG
Abemaciclib metabolite M18 (LSN3106729) is a metabolite of Abemaciclib and acts as a CDK inhibitor with antitumor activity. It has been utilized in conjunction with a CRBN ligand to engineer a PROTAC CDK4/6 degrader. The primary mechanism of action for CDK4/6 inhibitors involves the inhibition of retinoblastoma (RB) protein phosphorylation, leading to the induction of cell cycle arrest.
- Acts as a CDK inhibitor with antitumor activity.
- Utilized in conjunction with a CRBN ligand to engineer a PROTAC CDK4/6 degrader.
- Inhibits retinoblastoma (RB) protein phosphorylation.
- Induces cell cycle arrest.
- Promotes T-cell persistence and increases immunologic memory in mice that receive tumor-specific CD8+ T cells.
- Appears as an off-white to light yellow solid.
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